Computational Model Library

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Kristin Crouse | Published Wednesday, May 29, 2024

Identifying how organisms respond to environmental stressors remains of central importance as human impacts continue to shift the environmental conditions for countless species. Some mammals are able to mitigate these environmental stressors at the cellular level, but the mechanisms by which cells are able to do this and how these strategies vary among species is not well understood. At the cellular level, it is difficult to identify the temporal dynamics of the system through empirical data because fine-grained time course samples are both incomplete and limited by available resources. To help identify the mechanisms by which animal cells mitigate extreme environmental conditions, we propose an agent-based model to capture the dynamics of the system. In the model, agents are regulatory elements and genes, and are able to impact the behaviors of each other. Rather than imposing rules for these interactions among agents, we will begin with randomized sets of rules and calibrate the model based on empirical data of cellular responses to stress. We will apply a common-garden framework to cultured cells from 16 mammalian species, which will yield genomic data and measures of cell morphology and physiology when exposed to different levels of temperature, glucose, and oxygen. These species include humans, dolphins, bats, and camels, among others, which vary in how they respond to environmental stressors, offering a comparative approach for identifying mechanistic rules whereby cells achieve robustness to environmental stressors. For calibration of the model, we will iteratively select for rules that best lead to the emergent outcomes observed in the cellular assays. Our model is generalized for any species, any cell type, and any environmental stressor, offering many applications of the model beyond our study. This study will increase our understanding of how organisms mitigate environmental stressors at the cellular level such that we can better address how organisms are impacted by and respond to extreme environmental conditions.

A fisher directed management system was describeded by Hart (2021). It was proposed that fishers should only be allowed to exploit a resource if they collaborated in a resource management system for which they would own and be collectively responsible for. As part of the system fishers would need to follow the rules of exploitation set by the group and provide a central unit with data with which to monitor the fishery. Any fisher not following the rules would at first be fined but eventually expelled from the fishery if he/she continued to act selfishly. This version of the model establishes the dynamics of a fleet of vessels and controls overfishing by imposing fines on fishers whose income is low and who are tempted to keep fishing beyond the set quota which is established each year depending on the abundance of the fish stock. This version will later be elaborated to have interactions between the fishers including pressure to comply with the norms set by the group and which could lead to a stable management system.

Peer reviewed Correlated Random Walk (NetLogo)

Viktoriia Radchuk Thibault Fronville Uta Berger | Published Tuesday, May 09, 2023 | Last modified Monday, December 18, 2023

This is NetLogo code that presents two alternative implementations of Correlated Random Walk (CRW):
- 1. drawing the turning angles from the uniform distribution, i.e. drawing the angle with the same probability from a certain given range;
- 2. drawing the turning angles from von Mises distribution.
The move lengths are drawn from the lognormal distribution with the specified parameters.

Correlated Random Walk is used to represent the movement of animal individuals in two-dimensional space. When modeled as CRW, the direction of movement at any time step is correlated with the direction of movement at the previous time step. Although originally used to describe the movement of insects, CRW was later shown to sufficiently well describe the empirical movement data of other animals, such as wild boars, caribous, sea stars.

DARTS simulates food systems in which agents produce, consume and trade food. Here, food is a summary item that roughly corresponds to commodity food types (e.g. rice). No other food types are taken into account. Each food system (World) consists of its own distribution of agents, regions and connections between agents. Agents differ in their ability to produce food, earn off-farm income and trade food. The agents aim to satisfy their food requirements (which are fixed and equal across agents) by either their own food production or by food purchases. Each simulation step represents one month, in which agents can produce (if they have productive capacity and it is a harvest month for their region), earn off-farm income, trade food (both buy and sell) and consume food. We evaluate the performance of the food system by averaging the agents’ food satisfaction, which is defined as the ratio of the food consumed by each agent at the end of each month divided by her food requirement. At each step, any of the abovementioned attributes related to the agents’ ability to satisfy their food requirement can (temporarily) be shocked. These shocks include reducing the amount of food they produce, removing their ability to trade locally or internationally and reducing their cash savings. Food satisfaction is quantified (both immediately after the shock and in the year following the shock) to evaluate food security of a particular food system, both at the level of agent types (e.g. the urban poor and the rural poor) and at the systems level. Thus, the effects of shocks on food security can be related to the food system’s structure.

An Agent-Based Model of Space Settlements

Anamaria Berea | Published Wednesday, August 09, 2023 | Last modified Wednesday, November 01, 2023

Background: Establishing a human settlement on Mars is an incredibly complex engineering problem. The inhospitable nature of the Martian environment requires any habitat to be largely self-sustaining. Beyond mining a few basic minerals and water, the colonizers will be dependent on Earth resupply and replenishment of necessities via technological means, i.e., splitting Martian water into oxygen for breathing and hydrogen for fuel. Beyond the technical and engineering challenges, future colonists will also face psychological and human behavior challenges.
Objective: Our goal is to better understand the behavioral and psychological interactions of future Martian colonists through an Agent-Based Modeling (ABM simulation) approach. We seek to identify areas of consideration for planning a colony as well as propose a minimum initial population size required to create a stable colony.
Methods: Accounting for engineering and technological limitations, we draw on research regarding high performing teams in isolated and high stress environments (ex: submarines, Arctic exploration, ISS, war) to include the 4 NASA personality types within the ABM. Interactions between agents with different psychological profiles are modeled at the individual level, while global events such as accidents or delays in Earth resupply affect the colony as a whole.
Results: From our multiple simulations and scenarios (up to 28 Earth years), we found that an initial population of 22 was the minimum required to maintain a viable colony size over the long run. We also found that the Agreeable personality type was the one more likely to survive.
Conclusion We developed a simulation with easy to use GUI to explore various scenarios of human interactions (social, labor, economic, psychological) on a future colony on Mars. We included technological and engineering challenges, but our focus is on the behavioral and psychological effects on the sustainability of the colony on the long run. We find, contrary to other literature, that the minimum number of people with all personality types that can lead to a sustainable settlement is in the tens and not hundreds.

IMine is a flexible framework which can be adopt multiple criteria for convergence to solve Influence Minig problems. It can use any diffusion model, as well as resilience to compute the influence of a set of nodes base on the use case.
The code is written and tested on ‘R’ v3.5

The purpose of this model is to explore the influence of integrating individuals’ behavioral dynamics in an agent-based model of COVID-19, on the dynamics of disease transmission. The model is an agent-based extention of an established large-scale Individual-based model called STRIDE. Four risk factors determine the individual’s perception of the risk and how they behave accordingly. It is assumed that individuals with higher levels of risk perception adopt higher levels of contact reduction in their daily routines. Individuals can assign different weights to any of the four different risk factors, i.e., the modeler can model different populations and explore how the transmission dynamics vary among them.

Informal risk-sharing cooperatives : ORP and Learning

Victorien Barbet Renaud Bourlès Juliette Rouchier | Published Monday, February 13, 2017 | Last modified Tuesday, May 16, 2023

The model studies the dynamics of risk-sharing cooperatives among heterogeneous farmers. Based on their knowledge on their risk exposure and the performance of the cooperative farmers choose whether or not to remain in the risk-sharing agreement.

Peer reviewed Personnel decisions in the hierarchy

Smarzhevskiy Ivan | Published Friday, August 19, 2022

This is a model of organizational behavior in the hierarchy in which personnel decisions are made.
The idea of the model is that the hierarchy, busy with operations, is described by such characteristics as structure (number and interrelation of positions) and material, filling these positions (persons with their individual performance). A particular hierarchy is under certain external pressure (performance level requirement) and is characterized by the internal state of the material (the distribution of the perceptions of others over the ensemble of persons).
The World of the model is a four-level hierarchical structure, consisting of shuff positions of the top manager (zero level of the hierarchy), first-level managers who are subordinate to the top manager, second-level managers (subordinate to the first-level managers) and positions of employees (the third level of the hierarchy). ) subordinated to the second-level managers. Such a hierarchy is a tree, i.e. each position, with the exception of the position of top manager, has a single boss.
Agents in the model are persons occupying the specified positions, the number of persons is set by the slider (HumansQty). Personas have some operational performance (harisma, an unfortunate attribute name left over from the first edition of the model)) and a sense of other personas’ own perceptions. Performance values are distributed over the ensemble of persons according to the normal law with some mean value and variance.
The value of perception by agents of each other is positive or negative (implemented in the model as numerical values equal to +1 and -1). The distribution of perceptions over an ensemble of persons is implemented as a random variable specified by the probability of negative perception, the value of which is set by the control elements of the model interface. The numerical value of the probability equal to 0 corresponds to the case in which all persons positively perceive each other (the numerical value of the random variable is equal to 1, which corresponds to the positive perception of the other person by the individual).
The hierarchy is occupied with operational activity, the degree of intensity of which is set by the external parameter Difficulty. The level of productivity of each manager OAIndex is equal to the level of productivity of the department he leads and is the ratio of the sum of productivity of employees subordinate to the head to the level of complexity of the work Difficulty. An increase in the numerical value of Difficulty leads to a decrease in the OAIndex for all subdivisions of the hierarchy. The managerial meaning of the OAIndex indicator is the percentage of completion of the load specified for the hierarchy as a whole, i.e. the ratio of the actual performance of the structural subdivisions of the hierarchy to the required performance, the level of which is specified by the value of the Difficulty parameter.

If you have any questions about the model run, please send me an email and I will respond as soon as possible.
Under complex system perspectives, we build the multi-agent system to back-calculate this unification process of the Warring State period, from 32 states in 475 BC to 1 state (Qin) in 221 BC.

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