Computational Model Library

The Levers of HIV Model

Can Gurkan Wouter Vermeer Arthur Hjorth Uri Wilensky C. Hendricks Brown | Published Tue Mar 8 16:19:04 2022 | Last modified Mon Sep 19 15:20:59 2022

Chicago’s demographic, neighborhood, sex risk behaviors, sexual network data, and HIV prevention and treatment cascade information from 2015 were integrated as input to a new agent-based model (ABM) called the Levers-of-HIV-Model (LHM). This LHM, written in NetLogo, forms patterns of sexual relations among Men who have Sex with Men (MSM) based on static traits (race/ethnicity, and age) and dynamic states (sexual relations and practices) that are found in Chicago. LHM’s five modules simulate and count new infections at the two marker years of 2023 and 2030 for a wide range of distinct scenarios or levers, in which the levels of PrEP and ART linkage to care, retention, and adherence or viral load are increased over time from the 2015 baseline levels.

This project was developed during the Santa Fe course Introduction to Agent-Based Modeling 2022. The origin is a Cellular Automata (CA) model to simulate human interactions that happen in the real world, from Rubens and Oliveira (2009). These authors used a market research with real people in two different times: one at time zero and the second at time zero plus 4 months (longitudinal market research). They developed an agent-based model whose initial condition was inherited from the results of the first market research response values and evolve it to simulate human interactions with Agent-Based Modeling that led to the values of the second market research, without explicitly imposing rules. Then, compared results of the model with the second market research. The model reached 73.80% accuracy.
In the same way, this project is an Exploratory ABM project that models individuals in a closed society whose behavior depends upon the result of interaction with two neighbors within a radius of interaction, one on the relative “right” and other one on the relative “left”. According to the states (colors) of neighbors, a given cellular automata rule is applied, according to the value set in Chooser. Five states were used here and are defined as levels of quality perception, where red (states 0 and 1) means unhappy, state 3 is neutral and green (states 3 and 4) means happy.
There is also a message passing algorithm in the social network, to analyze the flow and spread of information among nodes. Both the cellular automaton and the message passing algorithms were developed using the Python extension. The model also uses extensions csv and arduino.

this agent-based model explores the dynamics of volunteer participation in urban community gardens, by combining behavioral theory and institutional theory

In the face of the COVID-19 pandemic, public health authorities around the world have experimented, in a short period of time, with various combinations of interventions at different scales. However, as the pandemic continues to progress, there is a growing need for tools and methodologies to quickly analyze the impact of these interventions and answer concrete questions regarding their effectiveness, range and temporality.

COMOKIT, the COVID-19 modeling kit, is such a tool. It is a computer model that allows intervention strategies to be explored in silico before their possible implementation phase. It can take into account important dimensions of policy actions, such as the heterogeneity of individual responses or the spatial aspect of containment strategies.

In COMOKIT, built using the agent-based modeling and simulation platform GAMA, the profiles, activities and interactions of people, person-to-person and environmental transmissions, individual clinical statuses, public health policies and interventions are explicitly represented and they all serve as a basis for describing the dynamics of the epidemic in a detailed and realistic representation of space.

This agent-based model was built as part of a replication effort of Jeness et al.’s work (linked below). The model simulates an MSM sexual activity network for the purpose of modeling the effects of respectively PrEP and ART on HIV prevention. The purpose of the model is to explore the differences between differerent interpretations of the NIH Indication Guidelines for PrEP.

a computer-based role-playing game simulating the interactions between farming activities, livestock herding and wildlife in a virtual landscape reproducing local socioecological dynamics at the periphery of Hwange National Park (Zimbabwe).

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