Computational Model Library

The Levers of HIV Model

Can Gurkan Wouter Vermeer Arthur Hjorth Uri Wilensky C. Hendricks Brown | Published Tue Mar 8 16:19:04 2022 | Last modified Mon Sep 19 15:20:59 2022

Chicago’s demographic, neighborhood, sex risk behaviors, sexual network data, and HIV prevention and treatment cascade information from 2015 were integrated as input to a new agent-based model (ABM) called the Levers-of-HIV-Model (LHM). This LHM, written in NetLogo, forms patterns of sexual relations among Men who have Sex with Men (MSM) based on static traits (race/ethnicity, and age) and dynamic states (sexual relations and practices) that are found in Chicago. LHM’s five modules simulate and count new infections at the two marker years of 2023 and 2030 for a wide range of distinct scenarios or levers, in which the levels of PrEP and ART linkage to care, retention, and adherence or viral load are increased over time from the 2015 baseline levels.

This agent-based model was built as part of a replication effort of Jeness et al.’s work (linked below). The model simulates an MSM sexual activity network for the purpose of modeling the effects of respectively PrEP and ART on HIV prevention. The purpose of the model is to explore the differences between differerent interpretations of the NIH Indication Guidelines for PrEP.

NetLogo HIV spread model

Wouter Vermeer | Published Fri Oct 25 16:51:17 2019

This model describes the tranmission of HIV by means of unprotected anal intercourse in a population of men-who-have-sex-with-men.
The model is parameterized based on field data from a cohort study conducted in Atlanta Georgia.

We compare three model estimates for the time and treatment requirements to eliminate HCV among HIV-positive MSM in Victoria, Australia: a compartmental model; an ABM parametrized by surveillance data; and an ABM with a more heterogeneous population.

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