EMMIT is an end-user developed agent-based simulation of malaria transmission. The simulation’s development is a case study demonstrating an approach for non-technical investigators to easily develop useful simulations of complex public health problems. We focused on malaria transmission, a major global public health problem, and insecticide resistance (IR), a major problem affecting malaria control. Insecticides are used to reduce transmission of malaria caused by the Plasmodium parasite that is spread by the Anopheles mosquito. However, the emergence and spread of IR in a mosquito population can diminish the insecticide’s effectiveness. IR results from mutations that produce behavioral changes or biochemical changes (such as detoxification enhancement, target site alterations) in the mosquito population that provide resistance to the insecticide. Evolutionary selection for the IR traits reduces the effectiveness of an insecticide favoring the resistant mosquito population. It has been suggested that biopesticides, and specifically those that are Late Life Acting (LLA), could address this problem. LLA insecticides exploit Plasmodium’s approximate 10-day extrinsic incubation period in the mosquito vector, a delay that limits malaria transmission to older infected mosquitoes. Since the proposed LLA insecticide delays mosquito death until after the exposed mosquito has a chance to produce several broods of offspring, reducing the selective pressure for resistance, it delays IR development and gives the insecticide longer effectivity. Such insecticides are designed to slow the evolution of IR thus maintaining their effectiveness for malaria control. For the IR problem, EMMIT shows that an LLA insecticide could work as intended, but its operational characteristics are critical, primarily the mean-time-to-death after exposure and the associated standard deviation. We also demonstrate the simulation’s extensibility to other malaria control measures, including larval source control and policies to mitigate the spread of IR. The simulation was developed using NetLogo as a case study of a simple but useful approach to public health research.

This code simulates individual-level, longitudinal substance use patterns that can be used to understand how cross-sectional U-shaped distributions of population substance use emerge. Each independent computational object transitions between two states: using a substance (State 1), or not using a substance (State 2). The simulation has two core components. Component 1: each object is assigned a unique risk factor transition probability and unique protective factor transition probability. Component 2: each object’s current decision to use or not use the substance is influenced by the object’s history of decisions (i.e., “path dependence”).

CapOvCWD is an agent-based model that simulates a captive cervid herd composed of adults and fawns. The model deer population is initialized using data on herd size and composition from captive facility records. Individual deer domiciliary history and annual CWD testing records inform the herd size and sample size (for CWD testing), respectively. The model can be used to iteratively estimate the facility level annual CWD detection probability. Detection probability estimates can be further refined by incorporating multiyear CWD testing data. This approach can be particularly useful for interpreting negative test results from a subset of the captive herd. Facility level detection probability estimates provide a comprehensive and standardized risk metric that reflects the likelihood of undetected CWD in the facility.

NetLogo model that allows scenarios concerning general social distancing, shielding of high-risk individuals, and informing contacts when symptomatic. Documentation includes a user manual with some simple scenarios, and technical information including descriptions of key procedures and parameter values.

Large outbreaks of Shigella sonnei among children in Haredi Jewish (ultra-Orthodox) communities in Brooklyn, New York have occurred every 3–5 years since at least the mid-1980s. These outbreaks are partially attributable to large numbers of young children in these communities, with transmission highest in child care and school settings, and secondary transmission within households. As these outbreaks have been prolonged and difficult to control, we developed an agent-based model of shigellosis transmission among children in these communities to support New York City Department of Health and Mental Hygiene staff. Simulated children were assigned an initial susceptible, infectious, or recovered (immune) status and interacted and moved between their home, child care program or school, and a community site. We calibrated the model according to observed case counts as reported to the Health Department. Our goal was to better understand the efficacy of existing interventions and whether limited outreach resources could be focused more effectively.