The Mission San Diego model is an epidemiological model designed to test hypotheses related to the spread of the 1805-1806 measles epidemic among indigenous residents of Mission San Diego during the early mission period in Alta California. The model community is based on the population of the Mission San Diego community, as listed in the parish documents (baptismal, marriage, and death records). Model agents are placed on a map-like grid that consists of houses, the mission church, a women’s dormitory (monjeria) adjacent to the church, a communal kitchen, priest’s quarters, and agricultural fields. They engage in daily activities that reflect known ethnographic patterns of behavior at the mission. A pathogen is introduced into the community and then it spreads throughout the population as a consequence of individual agent movements and interactions.

The St Anthony flu model is an epidemiological model designed to test hypotheses related to the spread of the 1918 influenza pandemic among residents of a small fishing community in Newfoundland and Labrador. The 1921 census data from Newfoundland and Labrador are used to ensure a realistic model population; the community of St. Anthony, NL, located on the tip of the Northern Peninsula of the island of Newfoundland is the specific population modeled. Model agents are placed on a map-like grid that consists of houses, two churches, a school, an orphanage, a hospital, and several boats. They engage in daily activities that reflect known ethnographic patterns of behavior in St. Anthony and other similar communities. A pathogen is introduced into the community and then it spreads throughout the population as a consequence of individual agent movements and interactions.