Computational Model Library

Our mission is to help computational modelers develop, document, and share their computational models in accordance with community standards and good open science and software engineering practices. Model authors can publish their model source code in the Computational Model Library with narrative documentation as well as metadata that supports open science and emerging norms that facilitate software citation, computational reproducibility / frictionless reuse, and interoperability. Model authors can also request private peer review of their computational models. Models that pass peer review receive a DOI once published.

All users of models published in the library must cite model authors when they use and benefit from their code.

Please check out our model publishing tutorial and feel free to contact us if you have any questions or concerns about publishing your model(s) in the Computational Model Library.

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GenoScope

Kristin Crouse | Published Wednesday, May 29, 2024 | Last modified Wednesday, April 09, 2025

GenoScope is a modular agent-based model designed to simulate how cells respond to environmental stressors or other treatment conditions across species. Genes, treatment conditions, and cell physiology outcomes are represented as interacting agents that influence each other’s behavior over time. Rather than imposing fixed interaction rules, GenoScope initializes with randomized regulatory logic and calibrates rule sets based on empirical data. Calibration is grounded in a common-garden experiment involving 16 mammalian species—including humans, dolphins, bats, and camels—exposed to varying levels of temperature, glucose, and oxygen. This comparative approach enables the identification of mechanisms by which animal cells achieve robustness under extreme environmental conditions.

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