Investigate spatial adaptive behaviors of narco-trafficking networks in response to various counterdrug interdiction strategies within the cocaine transit zone of Central America and associated maritime areas. Through the novel application of the ‘complex adaptive systems’ paradigm, we implement a potentially transformative coupled agent-based and interdiction optimization modeling approach to compellingly demonstrate: (a) how current efforts to disrupt narco-trafficking networks are in fact making them more widespread, resilient, and economically powerful; (b) the potential for alternative interdiction approaches to weaken and contain traffickers.